CORDIS Project
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This project investigates the role of the Kv1.5 ion channel in atrial fibrillation, a condition that increases stroke risk. By studying human heart cells and animal models, it aims to understand how mechanical stress and nitric oxide synthase affect ion channel regulation, potentially leading to new treatments for atri…
Atrial fibrillation (AF) is a leading risk factor for stroke and is a growing public health burden.
The condition is associated with pronounced electrical remodelling of the atria and can prove challenging to treat. A potential target for AF therapies is the repolarising potassium current IKur, carried by the atrial specific ion channel Kv1.5.
This channel is not found in the ventricles and therefore provides an attractive therapeutic target for the treatment of AF.
In atrial myocytes isolated f…
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