CORDIS Project
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This project investigates how cells prevent aneuploidy, a condition linked to cancer, by studying chromosome behavior during cell division. It focuses on two novel mechanisms: the segregation of acentric chromosomes via DNA tethers and the elongation of cells to accommodate long chromatids, ensuring proper division.
The mechanisms that safeguard cells against aneuploidy are of great interest as aneuploidy contributes to tumorigenesis.
To gain insight into these mechanisms, I studied the behavior of cells entering mitosis with damaged chromosomes. I used the endonuclease I-CreI to generate acentric chromosomes in Drosophila larvae.
While I-CreI expression produces acentric chromosomes in the majority of dividing cells, remarkably, it has no effect on adult survival.
Live studies reveal that acentric chromati…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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