CORDIS Project
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This project investigates the role of the ATMIN protein in DNA damage response and its impact on the ATM signaling pathway. By studying a specific mouse model, it aims to uncover how ATMIN influences genomic integrity and tumor suppression under various stress conditions.
The checkpoint kinase ATM (Ataxia Telangiectasia Mutated) transduces genomic stress signals to halt cell cycle progression and promote DNA repair in response to DNA damage. ATMIN (for ATM INteractor) is a cofactor for ATM that shares functional homologies with another cofactor, NBS1.
Whereas NBS1 is required for ATM function after induction of double-stand breaks (DSBs), ATMIN is essential for ATM signaling triggered by agents that induce ‘chromatin changes’ (including chloroquine and osmotic st…
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