CORDIS Project
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This research focuses on the role of specific genetic mutations in ATP-binding cassette transporters related to cholesterol metabolism in blood cancers. It aims to understand how these mutations contribute to disease progression and their potential impact on treatment strategies.
Background:
Altered high-density lipoprotein (HDL)-cholesterol homeostasis has been observed in hematologic malignancies but genetic evidences proving causality have been lacking.
The ability of HDL to promote cholesterol efflux depends on two ATP-binding cassette transporters ABCA1 and ABCG1, which exhibit anti-myeloproliferative activity in preclinical mouse models.Hypothesis:
Somatic mutations in ABCA1 and ABCG1 may be observed in myeloproliferative disorders and could be functionally inactiv…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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