CORDIS Project
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This project investigates the aggregation of the protein alpha-synuclein, which is linked to Parkinson's disease. By analyzing how mutations affect its phase separation and amyloid formation, the research aims to provide insights into the molecular mechanisms of neurodegeneration and develop strategies for potential in…
Protein aggregation hallmarks several neurodegenerative diseases, including Alzheimer's and Parkinson's.
In Parkinson's, aggregation of the intrinsically disordered protein (IDP) alpha-synuclein (Syn) leads to its intracellular deposition into Lewy bodies, which causes neuronal dysfunction.
Recently it was discovered that Syn can undergo liquid-liquid phase separation (LLPS), whereby a protein solution spontaneously separates into a dense and a dilute phase.
This process is initially reversible,…
TECHNICAL UNIVERSITY OF DENMARK DTU
DANMARKS TEKNISKE UNIVERSITET
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