CORDIS Project
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This project focuses on developing a new injectable therapy to prevent post-traumatic osteoarthritis (PTOA) by targeting microdamage in the subchondral bone following knee injuries. The research aims to understand the relationship between bone marrow lesions and microdamage, and to create alginate microparticles loaded…
Following nine years abroad I hope to work as a MSCA Fellow on post-traumatic osteoarthritis (PTOA), which is a sub-set of OA. OA is the most common skeletal disorder in the EU, affecting 40 million people. PTOA comprises about 12%, and this is expected to double by 2030, costing equivalent to 1% GDP.
Thus novel breakthroughs will have dramatic socio-economic impacts. PTOA occurs after an acute injury such as Anterior Cruciate Ligament (ACL) rupture of the knee.
After injury, direct cartilage da…
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