CORDIS Project
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This project investigates the genetic factors contributing to herpes simplex encephalitis (HSE) by identifying genes involved in the immune response to the herpes simplex virus-1. It focuses on understanding the role of specific genetic deficiencies in the innate immune system of affected individuals.
Herpes simplex encephalitis (HSE) is a rare disease affecting young children as well as adults due to primary infection with herpes simplex virus-1 (HSV-1). HSV-1 is a nearly ubiquitous virus commonly infecting humans however most do not develop HSE, suggesting that these children possess an underlying genetic susceptibility to HSV-1.
In addition, familial forms of HSE have been described, and in our HSE epidemiological study a relatively high incidence of consanguinity was found among HSE patie…
Université Paris Descartes
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