CORDIS Project
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This project focuses on developing new inhibitors targeting the DXS enzyme, crucial for multi-drug resistant pathogens. By employing dynamic combinatorial chemistry with chiral heterocycles, the aim is to discover effective anti-infective agents that could combat serious infections caused by resistant bacteria and para…
The emergence of multi-drug resistant pathogens is a serious global problem.
In this alarming situation, novel targets for which inhibitors with an unprecedented mode of action can be developed are urgently required.
This proposal aims at the development of selective and potent inhibitors of the important and underexplored anti-infective target DXS, an enzyme from the 2C-methyl-D-erythritol 4-phosphate pathway that is entirely absent in humans but is essential for medically relevant pathogens (e…
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
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