CORDIS Project
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This project examines chromatin rearrangements during the differentiation of embryonic stem cells into epiblast stem cells. It aims to understand how nuclear pore complexes influence gene positioning and expression, which is crucial for proper embryonic development.
During differentiation, cells undergo large-scale chromatin rearrangement, notably with the establishment of heterochromatin blocks at the nuclear periphery during the epiblast stage of development.
Concomitantly, hundreds of genes are relocated to and from the nuclear periphery and their position is correlated with their expression levels.
Most of these genes are associated with regulation of pluripotency, suggesting that the association of fLADs to the NL is a key parameter for proper embryoni…
THE UNIVERSITY OF EDINBURGH
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