CORDIS Project
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This project aims to analyze the composition and distribution of nuclear pore complex components using targeted mass spectrometry. By understanding their roles and interactions, the research seeks to advance knowledge in proteomics and structural biology.
The nuclear pore complex (NPC) is one of the most intricate multi-protein assemblies found in eukaryotic cells encompassing ~30 different components called nucleoporins (Nups).
The structural determination of the NPC represents a major challenge due to its size and location in the nuclear envelope.
Accurate quantitative data on NPC composition that are required to generate structural models at atomic resolution are currently lacking.
Here, I propose to apply targeted mass spectrometry to study t…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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