CORDIS Project
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This project focuses on understanding nonribosomal peptide synthetases, which are large enzymes that synthesize peptide-based natural products. By exploring their molecular mechanisms, the project aims to enhance the production of these therapeutically important compounds, which are often difficult to create through tr…
Many peptide-based natural products of therapeutic importance are synthesised by nonribosomal peptide synthetases (NRPSs), large, multifunctional enzymes that operate as molecular assembly lines, by coupling and processing an extending chain of amino acid monomers.
They are composed of numerous enzyme domains that carry out the steps of the bio-synthesis and provide an efficient route to natural products that are not easily accessible by synthetic chemistry.
An efficient exploitation, however, s…
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