CORDIS Project
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This project investigates the behavior of neural stem cells in the adult brain, particularly how aging affects their ability to generate new neurons. By distinguishing different stem cell subtypes, the research aims to uncover their regenerative potential and responses to aging.
In the adult neurogenic niches, neural stem cells (NSCs) generate neurons throughout life.
During aging, the number of newborn neurons is clearly reduced, although it is still very debated what specifically happens to the NSCs: do they die, increase their quiescence or change their fate?
It is emerging that NSCs are heterogeneous, with different subtypes, in particular quiescent and active NSCs, responding differently to neurogenic stimuli, including aging.
However, due to difficulties in distin…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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