CORDIS Project
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This project develops a biomimetic platform to study the nuclear pore complex, which regulates molecular transport in cells. By using solid-state nanopores and advanced optical techniques, it aims to investigate the structure and dynamics of proteins involved in nuclear transport at the single-molecule level.
The nuclear pore complex (NPC) is the gatekeeper of the nucleus that regulates the flow of all molecules across the nuclear envelope.
Remarkably, this ~40 nm wide pore is capable of efficient and fast transport while remaining highly selective.
Its dense central channel is composed of a highly dynamic spaghetti-like mesh of intrinsically disordered proteins that allows small molecules to pass freely, whereas large macromolecules (>40 kDa) rely on specific transporter proteins that ferry their ca…
TECHNISCHE UNIVERSITEIT DELFT
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