CORDIS Project
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This project investigates how transcription factors interact with nucleosomes to regulate gene expression. By developing a novel biochemical assay, it aims to uncover the structural mechanisms that allow these factors to access DNA within chromatin, focusing on their binding modes and the influence of nucleosome archit…
Transcription factors (TFs) regulate gene expression and govern cell identity.
In chromatinised genomes TF binding sites are frequently encapsulated in nucleosomes, which severely restrict access.
While specialised pioneer factors have been proposed to bind to these sterically hindered sites, the exact mechanism by which these factors access nucleosomes remains unknown. A number of biochemical models have been put forward that would allow DNA sequence read-out, these include: (i) TFs compatible…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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