CORDIS Project
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This project investigates how nuclear metabolism influences gene expression and cell fate during early embryonic development. By targeting metabolic enzymes in the nucleus, the research aims to reveal their roles in chromatin modifications and lineage specification, particularly during the implantation stage.
Embryogenesis involves dynamic epigenetic and transcriptional changes as the zygote divides and cells differentiate into embryonic (epiblast) and extra-embryonic (primitive endoderm and trophectoderm) lineages.
Metabolites serve as cofactors or substrates for chromatin-modifying proteins, thus shaping the global epigenetic landscape.
Intriguingly, during early development, multiple metabolic enzymes translocate to the nucleus where they might fuel chromatin modifiers.
How the interplay between n…
KOBENHAVNS UNIVERSITET
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