CORDIS Project
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This project investigates how the cell cycle influences the positioning of the mitotic spindle during cell division, focusing on epithelial morphogenesis in intestinal tissues. By utilizing advanced techniques like CRISPR, it aims to enhance understanding of spindle orientation and its implications for tissue organizat…
In multicellular organisms, oriented cell divisions sustain tissue morphogenesis, tissue architecture and homeostasis by ensuring the correct positioning of daughter cell after mitosis.
Accurate execution of oriented divisions and chromosome segregation relies on the positioning of an essential actor, the mitotic spindle.
The consequence of spindle misorientation is drastic.
Disruption of any of the spindle orientation factors could lead to genetic instability, tissue disorganization and tumorig…
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