CORDIS Project
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This project investigates the role of a kinase called NUAK1 in colorectal cancer, particularly in tumors driven by the WNT/Beta-catenin signaling pathway. It aims to evaluate NUAK1 as a therapeutic target by analyzing its impact on tumor initiation and growth.
Colorectal cancer (CRC) kills up to 170,000 Europeans annually.
Although survival rates have improved gradually, new treatment strategies are certainly needed.
Hyper-activation of WNT/Beta-catenin signalling occurs in up 93% of CRC cases and MYC appears to be an obligate effector of Beta-Catenin in the gut, making MYC an attractive target for therapeutic intervention. MYC, however, is difficult to target directly, owing to its lack of enzymatic activity or obviously druggable structural features…
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