CORDIS Project
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This project explores the role of the MITF transcription factor in regulating fatty acid metabolism and its impact on B-cell differentiation and lymphoma progression. The research aims to uncover how stress responses influence cancer cell behavior and transitions.
Metabolic reprogramming enables cells to adopt different phenotypes, providing flexibility in response to environmental stress, of particular relevance during tumour development. I recently demonstrated that the transcription factor MITF, known regulator of cell transitions in melanoma, controls the expression of the fatty acid (FA) desaturase SCD1.
The MITF/SCD1 axis maintains cell differentiation, while its suppression by starvation-induced Integrative Stress Response (ISR) originates dediffer…
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