CORDIS Project
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This research investigates the role of the mTOR protein kinase in muscle growth and metabolism, particularly its link to muscular dystrophy. By studying genetic mutations in mice, the project aims to uncover new diagnostic and therapeutic strategies for muscle diseases.
Mammalian Target Of Rapamycin (mTOR) is an evolutionary conserved protein kinase that integrates signals from growth factors, nutrients and cellular energy status to regulate cell proliferation, survival, growth and metabolism. mTOR functions have been inferred so far by employing rapamycin, an inhibitor that has therapeutical uses as immunosuppressive and anti cancer agent.
However rapamycin is not a general mTOR inhibitor because mTOR is part of at least two distinct multiprotein complexes, on…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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