CORDIS Project
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This project investigates how DNA is damaged by alkylating agents, which can lead to cancer. It aims to develop sensitive methods for detecting specific DNA adducts linked to dietary factors, particularly red meat, to assess cancer risk and identify biomarkers for health monitoring.
The exposure of DNA to alkylating agents can produce base adducts such as O6-alkylguanines, that if not repaired, can lead to a variety of effects including toxicity, mutagenicity and cancer.
Although exposure may be significant for certain individuals such as workers in the chemical industry and smokers, all individuals are exposed to alkylating agents from dietary components or that derive from reactive intermediates formed endogenously.
For example, nitrosation of dietary amines, amino acids…
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