CORDIS Project
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This project studies the genetic consequences of mitotic errors in cancer cells using patient-derived organoids. By combining real-time imaging with single-cell genome sequencing, it aims to link mitotic errors to genomic instability in esophageal adenocarcinoma.
Genomes from tumor cells are often grossly derailed in DNA content, with chromosomes gained, lost, fused or otherwise rearranged.
Presumably, many of these aberrations stem from mistakes during cell division, during which the DNA is normally divided equally to both daughter cells.
Cell division is often studied microscopically in 2D cell culture, while DNA sequences from cancer genomes are often re-constructed from tumor patient material.
As a consequence, there is still a poor understanding reg…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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