CORDIS Project
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This research investigates the role of the OCT4 transcription factor in maintaining pluripotency in stem cells and its function in germ cells. By analyzing how OCT4 interacts with specific regulatory elements, the project aims to deepen the understanding of stem cell biology.
The development of an organism requires the fine-tuned balance between self-renewal and differentiation of pluripotent cells.
Pluripotency is controlled by a group of transcription factors (TFs) that constitute the Pluripotency Gene Regulatory Network (PGRN). OCT4 is a core component of the PGRN and is required to specify pluripotency in vivo and to maintain pluripotency in vitro in embryonic stem cells (ESCs). OCT4 is also required for survival of unipotent primordial germ cells (PGCs).
However…
THE UNIVERSITY OF EDINBURGH
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