CORDIS Project
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The project investigates the death of osteocytes, the predominant cells in bone, and how this process influences local bone health. It aims to identify the mechanisms of osteocyte death and the resulting release of molecules that stimulate bone-resorbing cells, with implications for diseases like fractures and arthriti…
Osteocytes are long-lived cells within the bone matrix that have a variety of functions in the control of bone remodeling.
They are the most frequent cells of the bone by far and mediate the regulation of the mechanical loading-induced bone renewal at the systemic level.
Little is known how osteocytes die and how this process affects local bone homeostasis.
Nonetheless several local bone diseases such as fracture, osteonecrosis and arthritis are characterized by enhanced osteocyte death and loca…
UNIVERSITATSKLINIKUM ERLANGEN
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