CORDIS Project
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This project explores the relationship between dietary phytoestrogens, fibers, and obesity in explaining the male predominance of gastrointestinal adenocarcinomas. It aims to analyze data from various cohorts to understand how these factors contribute to cancer incidence.
The male predominance of adenocarcinomas in the gastrointestinal tract remains enigmatic.
Sex hormonal influence might play a key role in explaining this pattern.
Phytoestrogens, the plan derivatives with estrogenic properties, have shown clear anti-carcinogenic effects in vitro and animal studies.
Interestingly, phytoestrogens especially lignans (abundant in western diet) are generally found in fibre-rich plant food.
Whether phytoestrogens exert an independent effect or play a joint role togeth…
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