CORDIS Project
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This project investigates the dynamic behavior of ion channels using high-speed atomic force microscopy. It aims to uncover how reversible changes in ion channel structure can influence their function and implications for drug development.
Ion channels are transmembrane proteins regulating ion flux across cell membranes and are crucial for numerous physiological processes.
Hence, ion channels are implicated in many diseases.
To further drug development targeting ion channels, a comprehensive understanding is needed not only of their low-energy abundant states, but also of their rare and transient high-energy states, which play critical roles in channel function, regulation, and folding.
The cutting-edge high-speed atomic force mic…
WEIZMANN INSTITUTE OF SCIENCE
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