CORDIS Project
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This project aims to investigate the coordination of pre- and postsynaptic plasticity in neurons using a novel all-optical approach. By manipulating neuronal activity and imaging structural changes, it seeks to understand the molecular processes involved in learning and memory.
Communication between neurons in the brain occurs mainly via chemical synapses.
Activity-dependent changes in synaptic strength represent the cellular basis of learning and memory and depend on both the presynaptic terminal and the postsynaptic specialization.
Although postsynaptic strength and presynaptic transmitter release have been extensively studied in isolation, simultaneous investigation of pre- and postsynaptic potentiation at spine synapses is still a technical challenge.
The laborator…
Novartis Forschungsstiftung
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