CORDIS Project
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This project focuses on developing innovative vaccines using engineered bacterial Outer Membrane Vesicles decorated with a cancer-associated antigen. The goal is to enhance immune responses against colorectal cancer and explore the potential of combining this approach with existing cancer therapies.
This proposal originates from recent results obtained in the course of the Advanced ERC Project “OMVac”, the scope of which is to exploit the unique adjuvanticity properties of bacterial Outer Membrane Vesicles (OMVs) for developing innovative vaccines against infectious diseases and cancer.
In particular, Synthetic Biology was applied to engineer OMVs with FAT1, a tumour associated antigen expressed in most primary and metastatic colorectal cancers (CRC).
Using cancer models in immunocompetent…
UNIVERSITA DEGLI STUDI DI TRENTO
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