CORDIS Project
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This project explores how cancer cells adapt their energy production methods to support growth. By understanding the mechanisms of bioenergetic plasticity, it aims to identify potential therapeutic targets for improving cancer treatment outcomes.
Tumors reprogram their metabolism to fuel rapid growth.
Glycolysis and oxidative phosphorylation “OXPHOS” are the main energy-producing pathways.
For decades, metabolic reprogramming of tumors was perceived as only increased glycolysis (Warburg effect).
This dogma has recently been revised as we started to realize the importance of OXPHOS in tumor metabolism.
We are now entering a new era as metabolomics studies show that tumor metabolism is more heterogeneous than initially assumed.
In the prep…
TECHNISCHE UNIVERSITAET DRESDEN
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