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The Onco-Inflammation project investigates how inflammation contributes to genetic changes that lead to pancreatic ductal adenocarcinoma. By using mouse models, it aims to understand the mechanisms of genomic instability and identify potential therapeutic targets to block cancer progression.
Inflammation is suspected to be the first step leading to cancer due to alcohol consumption or tobacco smoking between others.
Little is known of how inflammation triggers genetic changes leading to tumorigenesis.
Recently, I show that TGFb, a cytokine present during inflammation, is able to generate aneuploidy, polyploidy and plausible chromosomal rearrangements in breast cells.
Such effects were mediated through the induction of the epigenetic reprogramming EMT.
In view to understand how infla…
FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD M.P.
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