CORDIS Project
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This project investigates how the tolerance of chromosome errors, or aneuploidy, during embryonic development parallels its role in cancer biology. By comparing human embryonic stem cells and colorectal cancer organoids, the research aims to uncover shared patterns that could inform new cancer therapies while preservin…
Can we study complex cancer biology by using a more predictable and structured model of embryogenesis?
Many of the hallmarks of cancer biology are shared with the biology of embryos: sustained proliferation, migratory behavior, angiogenesis, immune system suppression, and in my opinion the most fascinating: the tolerance of genome instability.Chromosome segregation errors and resulting aneuploidy are an important source of intratumor heterogeneity, therapy resistance, and metastasis in cancer. O…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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CALIFORNIA INSTITUTE OF TECHNOLOGYCORP
United States, Pasadena
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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