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OncoFlag is a platform that uses lipid nanoparticles to deliver messenger RNA, enabling tumor cells to express viral proteins. This approach enhances immune recognition of tumors, potentially improving cancer immunotherapy effectiveness across various cancer types.
Cancer immunotherapy has revolutionized oncology by leveraging the immune system to combat tumors.
However, many cancers evade immune detection through mechanisms like the absence of recognizable antigens (Ags), limiting current therapeutic efficacy.
To address this, we present OncoFlag, an innovative platform employing lipid nanoparticles (LNPs) to deliver messenger RNA (mRNA) encoding a protein of a target virus.
This approach transforms tumor cells into visible targets for the immune system b…
UNIVERSITAT POLITECNICA DE VALENCIA
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