CORDIS Project
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The ONCOFUM project investigates how metabolic changes, specifically the loss of Fumarate Hydratase enzyme, contribute to the development of Hereditary Leiomyomatosis and Renal Cell Cancer. By creating mouse models and analyzing tumor samples, the project aims to uncover the mechanisms of tumorigenesis and identify pot…
Cancer cells undergo profound metabolic changes.
However, little is known about whether and how metabolic changes drive cancer.
The discovery that mutations of Tricarboxylic Acid (TCA) cycle enzymes in mitochondria predispose to cancer gives evidence that dysregulated metabolism could drive tumorigenesis.
Amongst these, mutations in Fumarate Hydratase (FH) cause Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC), characterised by tumours of the skin and uterus, and renal cancer.
Patients in…
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THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom, Cambridge
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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