CORDIS Project
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This project aims to develop specific inhibitors targeting a protein involved in autophagy to combat cancer. By optimizing these compounds for oral use, it seeks to provide new therapeutic options for tumors that thrive in acidic environments.
The microenvironment of most solid tumors tends to be significantly more acidic than healthy tissue.
Inadequate perfusion, oxygen limitation and cell metabolic changes, are key causative factors for this situation.
The acidic pH induces a number of specific genetic, transcriptional and metabolic effects in tumor cells.
These are required for survival under increased H+-stress.
Evidence is now mounting that these effects also play a major role in tumor progression, invasiveness and the developmen…
UNIVERSITEIT ANTWERPEN
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