CORDIS Project
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This project investigates how oncogenes cause DNA replication stress, leading to genomic instability and mutations in human cancers. It aims to elucidate the underlying mechanisms and identify specific genes that support the proliferation of cells under such stress, which could inform cancer treatment strategies.
I recently proposed a model that helps explain the presence of p53 mutations and genomic instability in human cancers (Nature, 2005;
Nature 2006;
Science 2008).
The key features of this model are that oncogenes induce DNA replication stress, which in turn leads to DNA double-strand breaks, genomic instability and p53-induced senescence or apoptosis.
This model is relevant for almost all cancer types and explains the spectrum of mutations being reported in thousands of human cancers by the cancer…
UNIVERSITE DE GENEVE
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