CORDIS Project
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This project aims to engineer a light-activated P2X4 receptor to investigate its role in pain signaling. By using optogenetics in mice, the project seeks to understand the interactions between neurons and glial cells in chronic pain, potentially leading to new treatment strategies.
Pain has a large socio-economic impact, it is estimated that up to one in five Europeans (19%) suffers from chronic pain, costing the EU around €300 billion per annum.
Understanding the molecular and cellular mechanisms underlying pain signalling is critical for the development of novel treatments. P2X receptors are ligand-gated ion channels opened by extracellular ATP.
They have well-established roles in chronic pain, particularly in the case of P2X3, P2X4 and P2X7 subunits.
However, a lack of…
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