CORDIS Project
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The ORACLE project investigates the origins of Alzheimer’s disease by examining brain reserve throughout the lifespan, from prenatal development to old age. It aims to identify factors that influence brain reserve and its decline, using advanced imaging techniques and a large cohort study to enhance early detection and…
The origins of Alzheimer’s disease (AD) remain elusive.
The long pre-clinical phase of AD is universally recognized, but it is not known when predisposition for AD develops nor when the first signs and symptoms become discernable.
In this regard, an essential role is played by the ‘reserve’ capacity of the brain, which is built up in early life and acts as buffer against adverse risk factors later in life.
However, life-time trajectories of build up and loss of reserve and its determinants remai…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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