CORDIS Project
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This project explores the interaction between Notch signaling and CD133 in the differentiation and survival of oral epithelial cells. Using tooth development as a model, it aims to clarify how these pathways influence stem cell behavior and tissue formation.
Synergistic role of Notch and CD133 in oral epithelial cell differentiation and survivalThe Notch signaling is an evolutionarily conserved pathway that regulates cell-cell communication and cell fate. CD133/Prominin1 is often expressed by stem cells but its functions are still unknown.
Increasing evidence suggest Notch and CD133 might have close biological connection.
Based on my preliminary results, I hypothesize that Notch and CD133 play synergistic roles in regulating epithelial cell fates. U…
UNIVERSITY OF PLYMOUTH
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