CORDIS Project
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This project explores the communication between organelles in cells, focusing on the interactions between the endoplasmic reticulum and mitochondria. It aims to uncover the molecular mechanisms that facilitate metabolite transport and the physiological significance of these connections.
Organelles exchange metabolites and information to coordinate essential aspects of cellular physiology, thus behaving as an integrated intracellular network.
For example, the endoplasmic reticulum (ER) makes contacts with several organelles, including the plasma membrane, mitochondria, the Golgi apparatus, and lysosomes.
These contacts allow the coordination of calcium and lipid homeostasis across the cell.
Yet, little is known about their molecular nature. A long-standing question in cell biolo…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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