CORDIS Project
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This project investigates how diverse cell types emerge from a uniform population during development and regeneration. By utilizing advanced imaging and genetic techniques on mouse intestinal organoids, it aims to uncover the molecular mechanisms that drive cell diversity and the role of random events in this process.
Multicellular tissues, and ultimately complex organisms, are composed of multiple distinct cell types that differ in functional attributes.
Such diversity in cell composition (i.e. phenotypic diversity) arises during development and regeneration, where progenitor cells differentiate along multiple cell fate lineages to form a heterogeneous population.
While the molecular signals (i.e. cell states) that specify individual cell fates are widely studied, less is known about how multiple cell types…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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