CORDIS Project
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This project utilizes 'mini-gut' technology to study the interactions between gut microbiome and immune responses in colorectal cancer. By examining the molecular mechanisms at play, the research aims to provide insights into how these factors influence gut health and disease.
We pioneered the essential role of Wnt signals in adult stem cells, i.e. in intestinal crypts.
We also found that loss of the APC gene activates the Wnt pathway and causes colorectal cancer (CRC).
We then identified a Wnt target gene, Lgr5, which allowed us to define the crypt stem cells.
In a previous ERC grant based on these findings, we identified novel Lgr5 stem cells in multiple organs, and defined in vitro culture conditions to grow epithelial organoids from single Lgr5 stem cells.
Crucial…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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