CORDIS Project
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The project aims to develop innovative methods for mapping the origins of DNA replication across different tissues and conditions. By combining bioinformatics and genetics, it seeks to understand how replication is regulated and its implications for cancer and cellular processes.
Very little is known about the global organization and regulation of the replication program.
Recent advances in genomic methods allow the genome-wide description of the time of replication in mammals.
Nevertheless, the spatial information about replication initiations (origin of replication) is still sparse.
Such information is crucial for studying mechanistic aspects of replication regulation since the time of replication is determined mainly by the time each origin is activated.
In Originome…
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