CORDIS Project
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This research investigates how DNA replication origins are specified in higher eukaryotes, focusing on the role of the origin recognition complex. It aims to uncover the molecular mechanisms of DNA binding and the influence of chromatin structure on replication initiation.
Cellular life depends on the timely and accurate duplication of chromosomal DNA through semi-conservative replication to sustain genomic integrity and organismal viability.
In all domains of life, DNA replication relies on dedicated initiator proteins that recognize and bind specific genomic sites, termed replication origins, to facilitate the loading of ring-shaped replicative helicases onto DNA.
While origin recognition by initiators is determined by specific DNA sequences in prokaryotes and i…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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