CORDIS Project
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This project focuses on developing small molecule chemical probes to manipulate protein levels within human cells. By utilizing PROteolysis TArgeting Chimeric molecules, it aims to enhance drug discovery and therapeutic applications by controlling protein degradation without altering genetic material.
The development of potent, selective and cell-permeable small molecule chemical probes as tools to interrogate and modulate cellular functions of the human proteome is a rapidly growing field.
The direct manipulation of protein intracellular level and activity using small molecules has enormous potential to elucidate and validate new drug targets and therapeutics tools.
In the last decade, researchers have discovered an alternative method to directly control the level of protein components insi…
UNIVERSITY OF DUNDEE
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