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OrthoScript aims to develop a platform for creating and manipulating DNA and RNA with alternative genetic alphabets. This technology could enhance information storage capabilities and facilitate research into the relationship between genetic complexity and biological diversity, potentially transforming molecular biolog…
In OrthoScript, we aim to build a technology platform for the efficient synthesis, replication and evolution of DNA and RNA comprising alternative genetic alphabets that are either orthogonal to the natural alphabet or expand its combinatorial potential and information density.
Our approach involves the leveraging of protein design and evolution approaches to generate bespoke DNA and RNA polymerase enzymes for the encoded synthesis and sequencing of expanded genetic alphabets with high efficienc…
UNITED KINGDOM RESEARCH AND INNOVATION
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