CORDIS Project
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This project explores the role of a specific protein, OTULIN, in regulating immune responses. By studying its function in various immune processes, the project aims to enhance understanding of immune dysfunction and potential treatments for related disorders.
The immune system is essential for host defense against infections.
Methionine1-linked ‘linear’ ubiquitin chains (Met1-Ub) have emerged as a crucial activator of NF-κB transcription factors, which are vital to immune responses.
Recent findings suggest that defects in Met1-Ub signaling in humans can lead to severe immune dysfunction and cancer.
Met1-Ub is generated by the linear ubiquitin chain assembly complex (LUBAC).
Yet, how LUBAC and Met1-Ub signaling are regulated remains elusive.
We recent…
UNITED KINGDOM RESEARCH AND INNOVATION
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