CORDIS Project
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This project investigates the roles of specific proteins in insulin and adipokine production, focusing on their impact on metabolism. It aims to uncover new therapeutic targets for diabetes and insulin resistance by studying the mechanisms of oxidative protein folding in cells and mice.
Endoplasmic reticulum (ER) oxidation 1 (ERO1) trasfers disulfide bonds to protein disulfide isomerase (PDI) and is essential for oxidative protein folding in simple eukaryotes such as yeast and worms.
Higher eucaryotes have alternative pathways for disulfide bond formation (Zito et al., 2010).
Recently we have discovered that the ER localized peroxiredoxin 4 (PRDX4) is able to couple use of hydroperoxides for oxidative protein folding, independently of ERO1 (Zito et al., 2010b).
Hydrogen peroxid…
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