CORDIS Project
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This project investigates the proteostasis network's role in protein aggregation related to cancer, particularly focusing on mutant p53 proteins. It aims to understand how different cell states influence the aggregation process and its implications for tumorigenesis, especially in aging cells.
The concept of the proteostasis network (PN) represent a systems biology approach to protein deposition diseases (e.g. neurodegenerative diseases, amyloidoses, type II diabetes).
The PN includes all the cellular components involved in the synthesis, folding, and degradation of proteins, as well as the regulatory mechanisms required for maintaining a functioning proteome despite cellular stress, mutations, or protein misfolding.When the misfolded protein load exceeds the capacity of the PN to mai…
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