CORDIS Project
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This project focuses on understanding and stabilizing a specific mutant form of the p53 protein, which is crucial in cancer suppression. By exploring small molecules that can enhance the stability of this mutant, the research aims to develop new anti-cancer therapies targeting certain cancer cases worldwide.
Elimination of the tumour suppression activities of p53 is common to all cancers. p53 is inactivated directly by mutation in ~50% of human cancers, and ~30-40% of these oncogenic mutants are just temperature sensitive, ts, being active at lower temperatures.
Wild-type p53 spontaneously denatures, with a half-life of 10-20 minutes at body temperature, and ts mutants far faster.
The melting temperature and half life of ts oncogenic mutants can be raised by small molecules.
The mutant Y220C is part…
MEDICAL RESEARCH COUNCIL
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