CORDIS Project
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The PAINTBOX project aims to uncover the epigenetic mechanisms behind type 2 diabetes by analyzing pancreatic islets and environmental influences. It combines advanced sequencing and clinical studies to develop innovative strategies for prevention and treatment.
The prevalence of type 2 diabetes (T2D) is rapidly increasing worldwide and despite great efforts to prevent and cure the disease, the increase persist.
There is an urgent need to develop innovative and effective prevention and treatment strategies for T2D.
Recent genome-wide association studies were expected to uncover disease-causing mechanisms in common metabolic disorders.
Surprisingly, the identified genetic variants only explain a small proportion of the estimated heritability of T2D.
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