CORDIS Project
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This project explores the role of palmitoylation in the endoplasmic reticulum, focusing on how this lipid modification regulates protein functions and organelle architecture. It combines biochemical, functional, and modeling approaches to understand the palmitoylation network and its impact on cellular processes.
The endoplasmic reticulum (ER) is the largest intracellular organelle of mammalian cells.
It fulfills major functions such as folding and quality control of membrane proteins, lipid biosynthesis, calcium storage, and modulation of apoptosis.
This diversity of functions is accompanied by a complex 3D architecture, the maintenance of which is essential, since alterations lead to disease.
How this architecture is generated, how proteins localize to specific subdomains and how structure and function…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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